Caspase-1 (CASP1) is a cysteine protease which is an integral part of the
inflammasome and is involved in the proteolytic cleavage of inflammatory cytokines and
regulating cell apoptosis. Inhibition of CASP1 deters neurodegeneration and can delay the
onset of pre-symptomatic Alzheimer’s disease (AD). Various clinical trials have highlighted
the significance of dietary natural compounds (DNCs) in the prevention of AD. However,
these trials focused on exploring the efficacy of these compounds in already established
disease pathology. This research article evaluates the efficacy of DNCs against CASP1 in the
prevention of pre-symptomatic AD disease. To determine the interactive potential of DNCs,
an elaborate literature review was performed to look for those compounds involved in the
prevention of AD. Twenty-six compounds were obtained and these are commonly found in
fruits and vegetables. These compounds were further analysed with iGEMDOCK to
determine their affinity with the reported active site of CASP1. Among 26 compounds,
apigenin, chlorogenic acid, caffeic acid, epigallocatechin gallate, quercetin, petunidin and
syringic acid successfully interacted with the reported active site of CASP1. From this study,
we provide an insilico justification that these DNCs may prevent the onset of presymptomatic
AD and rescue neuronal integrity and synaptic plasticity from CASP1.