MAEJO INTERNATIONAL JOURNAL OF SCIENCE & TECHNOLOGY

Volume 16, No. 03, Month SEPTEMBER, Year 2022, Pages 179 - 189

Bioinformatic investigation of dietary natural compounds for prevention of onset of pre-symptomatic alzheimer’s disease by inhibiting caspase-1

Fahad Hassan Shah, Young Seok Eom, Song Ja Kim

Abstract Download PDF

Caspase-1 (CASP1) is a cysteine protease which is an integral part of the inflammasome and is involved in the proteolytic cleavage of inflammatory cytokines and regulating cell apoptosis. Inhibition of CASP1 deters neurodegeneration and can delay the onset of pre-symptomatic Alzheimer’s disease (AD). Various clinical trials have highlighted the significance of dietary natural compounds (DNCs) in the prevention of AD. However, these trials focused on exploring the efficacy of these compounds in already established disease pathology. This research article evaluates the efficacy of DNCs against CASP1 in the prevention of pre-symptomatic AD disease. To determine the interactive potential of DNCs, an elaborate literature review was performed to look for those compounds involved in the prevention of AD. Twenty-six compounds were obtained and these are commonly found in fruits and vegetables. These compounds were further analysed with iGEMDOCK to determine their affinity with the reported active site of CASP1. Among 26 compounds, apigenin, chlorogenic acid, caffeic acid, epigallocatechin gallate, quercetin, petunidin and syringic acid successfully interacted with the reported active site of CASP1. From this study, we provide an insilico justification that these DNCs may prevent the onset of presymptomatic AD and rescue neuronal integrity and synaptic plasticity from CASP1.

Keywords

pre-symptomatic neurodegeneration, caspase-1, dietary natural compounds, Alzheimer’s disease, molecular docking

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