WALAILAK JOURNAL OF SCIENCE AND TECHNOLOGY

Volume 17, No. 05, Month MAY, Year 2020, Pages 503 - 513

Prospect of plant-based flavonoids to overcome antibacterial resistance a mini-review

Abdi Wira SEPTAMA, Nordin SIMBAK, Eldiza Puji RAHMI

Abstract Download PDF

Although antibiotic has been frequently used for the treatment of infection, it has led to the emergence of resistant problem. Plant-derived compounds are alternative source for discovering novel therapeutics. Flavonoid is widely distributed and present in plant kingdom. This compound possessed several pharmacological properties including antibacterial. This review aims to present some information about the potency of flavonoids as antibacterial compound including their mechanism of antibacterial action as well as the relationship between their activity and flavonoid structure. The synergistic effect of flavonoids when used in combination with antibiotics against resistant bacterial is also described. Published literatures were collected from data bases such as PubMed, Google Scholar, Science Direct and Scopus. Scientific papers were selected based on information of antibacterial activity of flavonoid compounds. The information may provide an insight on the potency of flavonoid compounds to overcome resistant problem.

Keywords

Antibiotic, Antibacterial, Bacterial resistant, Flavonoid, Natural product, Synergistic

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