INTERNATIONAL JOURNAL OF AGRICULTURAL TECHNOLOGY
Volume 18, No. 01, Month JANUARY, Year 2022, Pages 231 - 240
Identification of lovastatin analogs-producing pleurotus cultivars in southern vietnam
Lam, V. N., Bui, N. T., Le, T. N., Dang, H. P., Nguyen, V. G. B., Ho, B.T. Q., Dinh, M. H., Nguyen, T. T. and Pham, N.D. H.
Pleurotus mushrooms have been widely cultivated worldwide due to their
nutritional and medicinal value. Numerous bioactive compounds such as polysaccharides,
polyphenols, proteins, and amino acids, have been well documented in its fruiting bodies.
However, lovastatin known as an anti-lipidemic medicinal compound produced by several
Pleurotus strains is neglected. This study aimed to identify local Pleurotus strains capable
of producing lovastatin analogs collected from southern Vietnam. Accordingly, 31
Pleurotus strains were isolated and belonged to 5 morphotypes: blue oyster, golden oyster,
abalone, oyster, and phoenix. Lovastatin analogs were detected using a state-of-the-art
method quantitative 1H nuclear magnetic resonance (qHNMR). As a result, among 31
strains of Pleurotus mushrooms, 4 strains were capable of synthesizing lovastatin analogs.
In which, one strain belonged to oyster morphotypes (Pleurotus ostreatus s. l.) and 3 strains
were phoenix morphotypes (Pleurotus pulmonarius s. l.). This is the first to identify the
production of lovastatin analogs by phoenix mushrooms.
Keywords
Lovastatin, 1H nuclear magnetic resonance qHNMR, Phoenix mushrooms, Pleurotus pulmonarius