Seaweeds are known sources of biologically active substances with diverse bioactive
properties important in the synthesis of medically important novel drugs. The bioactive
properties of brown macroalga, Padina australis Hauck were studied. Results showed that the
seaweed contain a total phenolic content of 13.85 ± 0.04 mg GAE/g. Antioxidant efficiency of
P. australis are characterized by having potent ABTS+
scavenging activity and high copper
reduction capacity with IC50 value of 138 μg/ml and 24.47 μg/ml respectively. Evaluation of
tyrosinase and elastase inhibition properties showed that P. australis extract has potent
inhibitory activity with IC50 of 32 μg/ml and IC50 of 93 μg/ml, respectively more effective than
kojic acid and tocopherol. In addition, in vitro assessment of alpha-glucosidase and alphaamylase inhibition property of the alga showed that P. australis extract have effective
inhibitory activity with IC50 values of 5.90 μg/ml and 41 μg/ml, respectively, more potent as
compared to acarbose (standard anti-diabetic drug). The seaweed extract exhibited potent
antibacterial activities against medically important bacterial pathogens such as Klebsiella
pneumoniae (Minimum Inhibitory Concentration (MIC) = 125 μg/ml), Methicillin-resistant
Staphylococcus aureus (MIC = 250 μg/ml), Pseudomonas aeruginosa (MIC = 125 μg/ml), and
Staphylococcus aureus (MIC = 250 μg/ml). The current investigation is a pioneering study in
the Philippines that shows the potential of P. australis as source of bioactive compounds with
important pharmacological applications.
Keywords
Biological activity; Chemical composition; Marine; Philippines; Seaweeds
INTERNATIONAL JOURNAL OF AGRICULTURAL TECHNOLOGY
Published by : Association of Agricultural Technology in Southeast Asia (AATSEA) Contributions welcome at : http://www.ijat-aatsea.com
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