SRINAGARIND MEDICAL JOURNAL

Volume 35, No. 05, Month SEPTEMBER, Year 2020, Pages 598 - 602

Cratoxylum formosum extract alleviates left ventricular hypertrophy in nitric oxide-deficient rats

Prapassorn Potue, Putcharawipa Maneesai, Upa Kukongviriyapan, Parichat Prachaney, Poungrat Pakdeechote

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Background and Objectives: Cratoxylum formosum (CF), Tiew Khao, is a local plant that exerts antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of CF extract on left ventricular (LV) hypertrophy and oxidative stress in nitric oxide-deficient rats. Methods: Male Sprague-Dawley rats were divided into 3 groups including control group received normal drinking water, Nω-nitro L-arginine methyl ester hydrochloride (L-NAME) group received L-NAME (40 mg/kg/day) for five weeks and L-NAME group treated with CF extract (500 mg/kg/day) for the last two weeks. At the end of experiment, heart weight, LV wall thickness and cross-sectional area, vascular superoxide production and plasma malondialdehyde were measured. Results: Rats received L-NAME showed LV hypertrophy and increases in oxidative stress markers (p<0.05). Treatment with CF extract significantly alleviated LV hypertrophy associated with reducing oxidative stress markers in L-NAME treated rats. Conclusion: CF extract alleviated LV hypertrophy in L-NAME rats which might be related with its antioxidant properties.

Keywords

Cratoxylum formosum LV hypertrophy nitric oxide-deficient rats oxidative stress

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