SRINAGARIND MEDICAL JOURNAL

Volume 35, No. 04, Month JULY, Year 2020, Pages 488 - 495

Protein serine-threonine kinases as drug target in cancer treatment

Sirinapha Klungsaeng, Laddawan Senggunprai

Abstract Download PDF

Serine-threonine kinases (STKs) are important regulators of intracellular signaling pathways. They regulate varieties of fundamental cellular processes including growth, proliferation, protein synthesis, metabolism, aging, and apoptosis. STKs are frequently dysregulated in human cancer. It is therefore, understanding of the characteristics of these proteins and their functions in signaling cascades is essential for development of new anti-cancer drugs. In this review, some STKS which implicated as cancer-driver are mentioned in term of their features as well as their roles in carcinogenesis. Additionally, drugs targeting these STKs are also reviewed.

Keywords

serine-threonine kinases, cancer, targeted drug, signaling pathway

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