ThaiScience  


SRINAGARIND MEDICAL JOURNAL


Volume 35, No. 02, Month MARCH, Year 2020, Pages -


Syzygium gratum extract attenuates renal fibrosis in l-name induced-hypertensive rats

Sarawoot Bunbupha, Kwanjit Apaijit, Sariya Meephat, Putcharawipa Maneesai, Parichat Prachaney, Poungrat Pakdeechote


Abstract Download PDF

extract has antioxidant, anticancer and vascular protective activities. This study aimed to investigate the effect of SG extract on blood pressure and renal remodeling in Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Methods: Male Sprague-Dawley rats were administered with L-NAME (40 mg/kg/day) in drinking water for 5 weeks in order to induce hypertension. Hypertensive rats were treated with SG extract (300 mg/kg/ day) or vehicle for the last 2 weeks. Systolic blood pressure and renal fibrosis were evaluated. Results: Rats treated with L-NAME had high systolic blood pressure (187.8 ± 5.1 mmHg vs. 124.4 ± 2.8 mmHg) and increases in renal tubulointerstitial (3.8 ± 0.1 % vs. 2.1 ± 0.2 %) and corpuscular fibrosis (11.3 ± 1.1 % vs. 4.8 ± 0.4 %) compared with control rats Conclusion: Our results indicate that SG extract decreased blood pressure and alleviated renal fibrosis in L-NAME-induced hypertensive rats. Keywords: Syzygium gratum, antioxidant, hypertension, renal fibrosis (p<0.05). Treatment of hypertensive rats with SG extract significantly reduced systolic blood pressure (154.7 ± 2.7 mmHg), and alleviated renal tubulointerstitial and corpuscular fibrosis (2.4 ± 0.1 % and 5.5 ± 0.4 % respectively) (p<0.05).


Keywords

None



SRINAGARIND MEDICAL JOURNAL


Published by : Faculty of Medicine, Khon Kaen University
Contributions welcome at : http://www.smj.ejnal.com/e-journal/journal/index.php