extract has antioxidant, anticancer and vascular protective
activities. This study aimed to investigate the
effect of SG extract on blood pressure and renal remodeling
in Nω-Nitro-L-arginine methyl ester hydrochloride
(L-NAME)-induced hypertensive rats.
Methods: Male Sprague-Dawley rats were administered
with L-NAME (40 mg/kg/day) in drinking water
for 5 weeks in order to induce hypertension. Hypertensive
rats were treated with SG extract (300 mg/kg/
day) or vehicle for the last 2 weeks. Systolic blood
pressure and renal fibrosis were evaluated.
Results: Rats treated with L-NAME had high systolic
blood pressure (187.8 ± 5.1 mmHg vs. 124.4 ± 2.8
mmHg) and increases in renal tubulointerstitial (3.8 ±
0.1 % vs. 2.1 ± 0.2 %) and corpuscular fibrosis (11.3
± 1.1 % vs. 4.8 ± 0.4 %) compared with control rats Conclusion: Our results indicate that SG extract decreased
blood pressure and alleviated renal fibrosis
in L-NAME-induced hypertensive rats.
Keywords: Syzygium gratum, antioxidant,
hypertension, renal fibrosis
(p<0.05). Treatment of hypertensive rats with SG extract
significantly reduced systolic blood pressure
(154.7 ± 2.7 mmHg), and alleviated renal tubulointerstitial
and corpuscular fibrosis (2.4 ± 0.1 % and 5.5
± 0.4 % respectively) (p<0.05).