The performance of the diffusion weighted magnetic resonance imaging using apparent diffusion coefficient measurement in detecting malignant liver lesions
Background and Objective: ADC (Apparent diffusion
coefficient) values have been shown to be helpful
for liver lesion characterization. There are; however,
discrepancies in the ADC values and controversies
regarding the optimal cutoff ADC values to
differentiates malignant from benign liver lesions. The
purpose of this study was to measure ADC values of
malignant liver lesions and to identify the optimal
cutoff ADC value to differentiate malignant from
benign liver lesions.
Material and Methods: A retrospective study of 180
MRI (Magnetic resonance imaging) of liver during June
1, 2012 to December 31, 2014. ADC value was
measured and compared between benign and
malignant liver lesions. The optimal ADC value to
differentiated between malignant and benign liver
lesions was calculated.
Results: Seventy-nine malignant liver lesions
included 52 CCAs, 20 HCCs, 7 liver metastases had median ADC value 1.06x10-3 mm2/sec. 101 benign
liver lesions included 44 hemangiomas, 11 FNHs, 7
hepatic adenomas and 39 cysts had median ADC
value 1.93x10-3 mm2/sec. The differences between
the median ADC values of malignant liver lesions
(1.06x10-3 mm2/sec) and benign liver lesions (1.93x
10-3 mm2/sec) was statistically significant (p<0.05). The
ADC value of <1.49x10-3 mm2/sec was the optimal
cut-off values to indicate malignant liver mass with
the sensitivity of 84.8%, specificity of 81.2%.
Conclusion: ADC value is useful for differentiating
malignant from benign liver lesions with1.49x10-3
mm2/s as optimal cutoff ADC value