Volume 36, No. 01, Month JANUARY, Year 2021, Pages 15 - 23

Comparison of acute radiation dermatitis between hypofractionated and conventional radiotherapy in postmastectomy breast cancer

Sawanee Nirunsiriphol

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Objective: To compare the acute radiation dermatitis between hypofractionated radiotherapy (HFRT) and conventional radiotherapy (CRT) in postmastectomy breast cancer. Methods: This study was the experimental research design (randomized controlled trial). Seventy six patients underwent a mastectomy and divided into two groups with 38 cases in group I used HFRT regimen 42.56 Gy in 16 fractions over three weeks and 38 cases in group 2 used CRT regimen 50 Gy in 25 fractions over five weeks. The study was performed at Division of Radiation Oncology, Roi Et Hospital, from January 1, 2019, to April 30, 2020. All cases were categorized in different grading of acute radiation dermatitis by Radiation Oncologist at Week 1,2,3 during radiation and 1 month, 3 months post-radiation. The statistical analyzed were used descriptive statistics and Z-test. The statistical significance was set at p<0.05. Results: There was no significant difference of acute radiation dermatitis in CRT and HFRT. We found that acute radiation dermatitis grade 1 at week 1,2and 3 during radiotherapy of CRT vs HFRT was 5.26% vs.7.89% (p=0.644), 28.95% vs. 18.42% (p=0.280), 50% vs. 28.95% (p=0.085), respectively. Acute radiation dermatitis grade 1 of the first-month postmastectomy radiation was 15.79% vs. 10.53% (p=0.301) in patients treated with CRT vs. HFRT. Dermatitis grade 1 was the most common grade for acute radiation dermatitis


Breast cancer; radiotherapy; acute radiation dermatitis; hypofractionated


Published by : Faculty of Medicine, Khon Kaen University
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