THAMMASAT INTERNATIONAL JOURNAL OF SCIENCE & TECHNOLOGY

Volume 26, No. 02, Month APRIL, Year 2021, Pages 128 - 137

Hexane extract of seaweed caulerpa lentillifera inhibits cell proliferation and induces apoptosis of human glioblastoma cells

Varitta Tanawoot, Pornpun Vivithanaporn, Tanapan Siangcham, Krai Meemon, Nakorn Niamnont, Prasert Sobhon, Montakan Tamtin, Kant Sangpairoj

Abstract Download PDF

Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.

Keywords

Caulerpa lentillifera, Seaweed, Glioblastoma, Proliferation, Apoptosis

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