This study investigated the effect of aged garlic extract (AGE) on spatial learning and memory ability using Morris
water maze (MWM) test in amyloid- (A) induced-neurotoxicity rats. Pretreatment of AGE at oral doses of 125, 250 and 500
mg/kg for 8 weeks significantly prevented the learning and short-term memory impairment in A-induced neurotoxicity rats.
Histological analysis has shown that pretreatment of AGE reversed the neuron loss in the CA1 and CA2 regions of hippocampus
of A-induced neurotoxicity in a comparable effect of ascorbic acid. By DPPH and FRAP determination, AGE had high
antioxidative activity. Pretreatment of AGE caused significant increases of superoxide dismutase (SOD) and glutathione
peroxidase (GPx) activities, no significant change in catalase (CAT) activity, and a significant decrease of malondialdehyde
(MDA) level of the A-induced rat brain homogenate. The results suggest that AGE ameliorates the cognitive dysfunction in A-
induced neurotoxicity rats via its antioxidative effect.
Keywords
ed garlic extract, hippocampus, Morris water maze, oxidative stress, spatial memory
SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY
Published by : Prince of Songkla University Contributions welcome at : http://rdo.psu.ac.th
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