Chaetomium brasiliense was used in this study to control rice brown spot disease
pathogen, Drechslera oryzae. The result of bi-culture test showed that Ch. brasiliense gave the
hightest percentage of growth inhibition at 26.38% and had the highest spore inhibition at
23.81%. In crude extracts test, it was found that crude methanol extract obtained from Ch.
brasiliense at 1000 ppm showed the highest inhibitory effect on colony growth and spore
production. Ch. brasiliense gave a growth inhibition and spore inhibition rates at 83.50 and
99.78% respectively. The effective dose (ED50) on growth and spore inhibition of Ch.
brasiliense was 80.54 and 0.35 μg/ml, respectively. It was also found that Nano-particles
obtained from crude methanol extract of Ch. brasiliense (nano CBM) at 10 ppm had the best
inhibitory effect in terms of growth and spore inhibition. Nano CBM can inhibit the growth at
70.00% and spore production at 79.92%. The ED50 values for spore inhibition of Ch.
brasiliense was 2.86 μg/ml.