This study aims to examine incidence, characteristics, and trend of ADR-related admissions at one tertiary care hospital in Thailand during a five-year period (2007-2011), using administrative database and spontaneous report. Data of all hospitalized patients during the year 2007 to 2011 were retrospectively obtained from routine administrative database. The 10th International Classification of Diseases (ICD-10) was used to identify patients with ADR. The number of admissions with the following diagnosis codes; “adverse drug reaction”, “drug-induced”, “due to drug”, “due to medicament”, “drug allergy” or “external causes code” (Y40-Y59) were obtained and analyzed. During the year 2007 to 2011, incidence of ADR-related hospital admissions detected through hospital database and spontaneous report was estimated at 2.74%, and 0.71%, respectively. Using the administrative database, incidence of ADR-related hospital admissions was increasing from 1.29% (2007) to 3.75% (2010) and then slightly decreasing to 3.47% in 2011. The most commonly involved drugs were hormones and their synthetic substitutes and antagonists (Y42; 23.8%), systemic antibiotics (Y40; 13.2%), agents primarily affecting blood constituents (Y44; 12.6%), and primarily systemic agent (Y43; 9.3%), respectively. Drug-induced neutropenia (46.35%), drug-induced hypoglycemia without coma (27.01%), and generalized skin eruption (11.06%) were the three most common ADRs identified from database. ADR-related hospital admission was an increasing important public health problem. Effort should be made to implement effective measure to reduce ADRs and to make greater use of administrative database to continuously monitor patient safety in national perspective.
Keywords
Adverse drug reaction, spontaneous report, database, pharmacovigilance, admission, monitoring