Volume 46, No. 01, Month JANUARY, Year 2019, Pages 25 - 32

Effect of mode of superdisintegrant incorporation on tableting properties of metronidazole granules

Yonni Eshovo Apeji, Fidelis Dzarma Zechariah, Sophie Nock Anyebe, Babajide Tytler, Adeniji Kehinde Olowosulu, Avosuahi Rukayat Oyi

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Superdisintegrants are a special class of excipients used in a tablet formulation to aid disintegration and possibly enhance the release kinetics of a drug. The intragranular and extragranular effect of sodium starch glycolate (SSG) or croscarmellose sodium (CCM) as superdisintegrants on tableting properties of metronidazole granules were investigated. The granules were characterized for particle size analysis, angle of repose, bulk and tapped densities as well as Carr’s index (CI) and Hausner’s ratio (HR). Tablets were prepared from each batch of granules weighing 500 mg on a single punch tablet press using 12 mm flat-faced punches and compressed at 57.5 MPa. The tablets were kept at 25 ± 2 °C/75 % RH for 24 h to allow for elastic recovery and the properties of weight variation, content uniformity, thickness, crushing strength (CS), disintegration time (DT), and drug-release were evaluated. The results showed that all the batches of granules exhibited good flow based on angle of repose < 30° , CI < 20 %, and HR ≤ 1.2. The evaluated tablet properties demonstrated that intragranular addition of either SSG or CCM lowered the CS and DT when compared to the extragranular effect. This indicates that the incorporation mode of superdisintegrant in a tablet formulation exerts an influence on tablet properties.


Croscarmellose sodium; Sodium starch glycolate; Disintegrant; Extragranular; Intragranular; Wet granulation


Published by : Faculty of Pharmacy, Mahidol University
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