Tuberculosis recorded as the 9th cause of death worldwide and Indonesia becomes the 2nd country with the highest tuberculosis incidence in the world. The previous study showed that tuberculosis can affect the patients’ quality of life and high level of expenditures, so a study is needed to link both of them. In this study, a cost-utility analysis was conducted to see how the DOT (Directly Observed Treatment) and SAT (Self-Administered Treatment) influence the patient"es quality of life and how much cost for each method. This study used a cross-sectional design with primary data and secondary data collection. The subjects were tuberculosis category I patients aged 18 years and over at Gatot Soebroto Army Hospital. Utilities were obtained with the help of the EQ-5D-5L questionnaire and the costs used were viewed from a social perspective with the components of direct medical costs, direct non-medical costs, and indirect costs. The results obtained in this study was the utility value of 0.718 with total expenses 5.499.656,00 IDR in the DOT group (n=12) and the utility value of 0.912 with the total expenses 5.804.887,00 IDR in the SAT group (n=30). Based on these values, the average cost-utility ratio in the DOT group was 7.659.688,02 IDR, in the SAT group was 6.365.007,67 IDR, and an incremental cost-utility ratio was 1.573.355,67 IDR/utility. The results showed that both methods can be selected according to the available resources, especially funds.