ENGINEERING JOURNAL CHIANG MAI UNIVERSITY

Volume 27, No. 02, Month AUGUST, Year 2020, Pages 191 - 200

Impact pressure and behavior of liquid jet generated from idm needle free-jet injection powered by spring and gas

Phontree Wongprasan, Wirapan Seehanam, Kamonchanok Ura and Kulachate Pianthong

Abstract Download PDF

This research is to investigate the characteristic and impact pressure of the high speed liquid jet which is generated on the principle of Impact Driven Method (IDM) for the application of drug delivery through the skin. High speed liquid jet was generated from IDM needle free- jet injection device which use spring and gas as the power sources. In this study, projectile with momentum around 0.3 - 1.1 kg.m/s are used with the nozzle having 0.2 and 0.3 of orifice diameter and 0.2 and 0.5 ml of containing volumes. It is found that the devices generate the maximum impact pressure of around 5 - 90 MPa, These will increase when the momentum of the projectile is increased and the volume of the nozzle container is decreased. The impact pressure profiles is found highly fluctuated because of the pulsing characteristics during the injection. These phenomena is clearly seen with devices that uses gas rather than springs as power. The pulse characteristics will enhances the jet efficiency due to the better penetration and dispersion of the drugs into the tissue target. Therefore, for drug delivery, the gas powered device will provide a more appropriate characteristics of jets giving a better delivery that than the jet powered by the spring.

Keywords

High-speed water jet, Impact Driven Method, PVDF, Jet impact pressure

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