CHIANG MAI UNIVERSITY JOURNAL OF NATURAL SCIENCES

Volume 18, No. 04, Month OCTOBER, Year 2019, Pages 515 - 515

Succinic acid as a green and bio-based catalyst assisted solvent-free one-pot biginelli synthesis of biologically active 3,4-dihydropyrimidin-2-(1h)-ones/thiones derivatives

Farzaneh Mohamadpour and Mansoor Feilizadeh

Abstract Download PDF

Succinic acid as a bio-based green and versatile catalyst has been employed for one-pot facile three-component Biginelli synthesis of 3,4- dihydropyrimidin-2-(1H)-ones/thiones derivatives under solvent-free conditions with high to excellent yields and short reaction times. This sustainable procedure has notable benefits such as easy-to-handle, green, low-cost and non-toxic catalyst, materials available, simple work-up with no necessity of chromatographic purification steps, one-pot and solvent-free conditions. The products have been characterized by melting points and 1H NMR spectroscopy.

Keywords

Succinic acid, 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives, Sustainable procedure, Biginelli condensation reaction, Solvent-free conditions.

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