CHIANG MAI UNIVERSITY JOURNAL OF NATURAL SCIENCES

Volume 18, No. 04, Month OCTOBER, Year 2019, Pages 427 - 442

Anticancer activity of metal complexes with acesulfame mixed with triphenylphosphine ligands

Bussaba Boonseng, Teerawat Khudkham, Sutthida Wongsuwan, and Jaruwan Chatwichien

Abstract Download PDF

Metal complexes of silver(I), nickel(II) and copper(II) with the mixed ligands of acesulfame (ace) and triphenylphosphine (PPh3) were prepared in this work. The complexes of [Ag(ace)]n (1), [Ag(ace)(PPh3)] (2), [Ni(ace)2(H2O)4] (3),[Ni(ace)2(PPh3)2] (4), [Cu(ace)2(H2O)2] (5) and [Cu(ace)2(PPh3)2] (6) were characterised by FT-IR and NMR spectroscopy, Mass spectrometry including X-Ray powder diffraction. The synthesised complexes were examined in their anticancer activity against A549 lung cancer cells which were further evaluated their efficiency by IC50 method. [Ag(ace)]n (1), [Ni(ace)2(H2O)4] (3) and [Cu(ace)2(H2O)2] (5) which contain only acesulfame ligand exhibited higher IC50 values in comparison to the mixed ligands of ace and PPh3. [Ag(ace)(PPh3)] (2), [Ni(ace)2(PPh3)2] (4) and [Cu(ace)2(PPh3)2] (6) displayed the inhibition in the growth of cancer cells with IC50 values of 1.65, 13.45 and 1.06 μM, respectively. Additionally, silver(I) and copper(II) complexes also presented better activity than the standard Etoposide (IC50 5.623 μM). The results indicated that the mixed ligands could perform more excellent inhibition of cancer cells growing in comparison to the using of only acesulfame or triphenylphosphine ligand.

Keywords

Complexes, Acesulfame, Anticancer, Triphenylphosphine

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