The objective of this research paper is to search for setup-time reduction in mold change of injection process. From surveying in a plastic injection process, an injection molding machine in 260 tons capacity with two-nozzle type takes long setup time in mold change about 194.36 minutes. There are two main activities 1) mold change: preparing tools, connecting water pipes and changing tool in fixing clamp and 2) parameter adjustment. Quick changeover technique; separate internal activities (those can only be performed when the machine is stopped) and external activities (those can be done while the machine is still running), convert internal to external activities and streamline all activities, is applied to reduce setup time. Internal activities with setup time five minutes more are selected then utilize why-why analysis, visual control, tool replacement and preventive maintenance as improvement tools. The result reveals that setup time is decreased from 194.36 minutes to 131.40 minutes. Reduction time is 62.56 minutes which is 32.19%.