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ENGINEERING JOURNAL CHIANG MAI UNIVERSITY


Volume 25, No. 02, Month AUGUST, Year 2018, Pages 1 - 10


Control of active ingredient content in external use drug manufacturing

Laortong Kestong,Jittra Rukijkanpanich


Abstract Download PDF

In the external use drug manufacturing, it was found that the active ingredient content tend to be less than the specification. The objective of this research was to improve the manufacturing process in order to control the content of active ingredient to meet the specification. According to root causes that affected the reduction of content were (1) the sequence of fill materials in the chemical solution was not suitable as a result of chemical reaction, (2) tool and method for spinning the solution in 3,000 liter tank was inappropriate, the solution and its active ingredient was not homogeneous. Therefore, the countermeasures were (1) sequencing of fill materials in the chemical solution based on pH, (2) installation of a pump to stir the chemical solution homogeneous. The result revealed that the active ingredient content could meet the specification.


Keywords

External Use Drug, Active Ingredient Content, Ingredient Content Control



ENGINEERING JOURNAL CHIANG MAI UNIVERSITY


Published by : Faculty of Engineering Chiang Mai University
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